作者： 段昌萍 王永丽 牛桂梅 唐玉根
【摘要】 目的: 研究治疗外阴上皮内非瘤样病变的新方法。方法: 将93例该病患者随机分为实验组和对照组，实验组病人68例采用自制中药方剂愈白汤水煎坐浴，每日三次，每次30min，三个月为一疗程。对照组25例采用肤轻松软膏及丙酸睾丸素外涂。结果: 实验组病人68例，治愈52例，治愈率7647%；有效10例，有效率1471%；总有效率9118%。 对照组病人25例,治愈1例,治愈率4%；有效10例,有效率40%；总有效率44%。结论: 愈白汤治疗外阴上皮内非瘤样病变效果显著，且无毒副作用，可推广使用。
【关键词】 外阴上皮内非瘤样病变; 愈白汤
【ABSTRACT】 Objective: To investigate the new therapy for nonneoplastic epithelial disorders of skin and mncosa. Methods: 25 patients in the control group were applied to ointment with fluocinoloni acetonidum and oinment with testosterone propionate,and 68 patients in the research group took hip bath with Chinese traditional medicine Yubai Tang to clean the genital organs, three times every day,30 minutes every time, and three months were taken as a period of treatment. Results: In the research group, there were 52 patients who had been cured,the cured ratio was 7647%, 10 patients had effect,the effect ratio was 1471%,and so the total effect ratio was 9118%. In the control group,there was 1 patient who had been cured (cured ratio 4%),10 patients had effect (effect ratio 40%),the total effect ratio was 44%. So it is remarkably significant to compare the curative effects for the two groups（P<001 ）. Conclusion： Traditional Chinese medicine Yubai Tang has obvious therapeutic effect on nonneoplastic epithelial disorders of skin and mncosa without poisonous and ill effect, and so this kind of new therapy can be generalized.
【KEY WORDS】 Nonneoplastic epithelial disorders of skin and mncosa; Yubai Tang
外阴上皮内非瘤样病变是女性外阴皮肤和粘膜组织发生变性及色素改变的一组慢性疾病。因病变部位皮肤和粘膜多呈白色，故又称其为外阴白色病变。本病病程较长，复发率高，目前无特效治疗方法。为研究治疗此病的新方法，我们将20031~200512月于河北省怀来县医院门诊就诊的患此病病人93例，随机分对照组和实验组进行观察治疗；对照组25例采用肤轻松软膏及丙酸睾丸素外涂；实验组68例病人给予中药愈白汤治疗，结果报道如下[1，2]。
1 资料与方法
11 一般资料 河北省怀来县医院20031~200512月门诊经病理检查确诊为本病的93例病人,随机分为两组。实验组68例，采用中药愈白汤坐浴治疗；对照组25例，局部外用肤轻松及丙酸睾丸素软膏。93例病人中，硬化性苔癣50例，鳞状上皮细胞增生43例，两组病人年龄、病程、病理分型上均无显著性差异（P<005）。
12 方法 中药愈白汤由以下中药组成:黄芪60g、淫羊藿30g、丹参2
20g、野百合20g、山慈姑10g、苍术20g、生地20g、白花蛇舌草30g、赤勺20g、白术20g、黄柏20g、地肤子20g、土茯苓30g。以上药物布包水煎,熏洗坐浴,每日2~3次，每次30min，3个月为一疗程。对照组外阴涂擦肤轻松软膏及丙酸睾丸素软膏，每日一次，30d为一疗程。
13 疗效判定标准 痊愈:症状消失, 外阴皮肤粘膜颜色、弹性基本恢复正常，病理检查为“正常皮肤和粘膜”。有效：症状消失，原白色病变区域缩小、变红，或部分转为褐色。无效：症状无缓解，病变区皮肤面积未缩小或反而增大[3,4]。
1４ 统计方法 采用χ2检验
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